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Verapamil Hydrochloride Tablets BP PR/ Film-Coated

Verapamil Hydrochloride BP tablets for prescribed cardiovascular indications. The supplied product text describes separate 40 mg prolonged-release and 80 mg film-coated presentations.

Product Overview

40 mg: Verapamil Hydrochloride BP 40 mg, described as prolonged-release in supplied text; release designation requires verification against registered product specifications.

80 mg: Each film-coated tablet contains Verapamil Hydrochloride BP 80 mg; prolonged-release is not confirmed for this strength.

Therapeutic class: Non-dihydropyridine calcium-channel blocker / Cardiovascular agent.

Manufacturer named in brief: Healthy Life Pharma Pvt. Ltd. Exporter named: Healthy Inc. Certifications require documentary verification.

B2B enquiries: +91 7710003340

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Product Information

Verapamil Hydrochloride Tablets BP PR/ Film-Coated is listed for pharmaceutical business-to-business enquiries. Exact active ingredients, formulation, strength, pack configuration and manufacturer details should be confirmed against the product label and approved technical documentation before ordering.

Description

1. Product Introduction

Verapamil hydrochloride is a non-dihydropyridine calcium-channel blocker used for certain cardiovascular conditions, including hypertension, angina and selected supraventricular arrhythmias, depending on the approved formulation and jurisdiction.

The supplied labels describe 40 mg prolonged-release and 80 mg film-coated tablets. These should not be treated as interchangeable formulations. In particular, a 40 mg prolonged-release presentation is unusual compared with more common higher-strength modified-release products; the release claim must be confirmed with approved labeling and dissolution data before marketing.

Healthy Life Pharma Pvt. Ltd. and Healthy Inc are named as manufacturer and exporter in the supplied brief; certifications and manufacturing capabilities require verification.

2. Product Specifications

Product nameVerapamil Hydrochloride Tablets BP
Active ingredientVerapamil Hydrochloride BP
Presentation A40 mg tablet, described as prolonged-release (PR); verify registered release profile
Presentation B80 mg film-coated tablet; release mechanism not specified on supplied label
StandardBP as stated in supplied product text
Therapeutic classNon-dihydropyridine calcium-channel blocker
Other strengths120 mg and 240 mg mentioned in promotional text, not confirmed by supplied labels
Packaging and shelf lifeTo be confirmed from approved registration and stability data

3. Manufacturing Technology

Verapamil tablet manufacturing requires control of identity, content uniformity, compression, coating and dissolution. A prolonged-release product additionally requires validated release-control technology and a formulation-specific multipoint dissolution profile.

Hydrophilic matrix systems are one possible modified-release approach, but the exact technology and claimed 24-hour release of the supplied 40 mg product cannot be assumed without approved manufacturing records and clinical/pharmacokinetic support. The 80 mg film-coated product must be assessed independently.

4. Quality Assurance

  • Identity, assay, impurities and dosage-unit uniformity testing against approved product specifications.
  • For verified PR tablets, multipoint dissolution/release testing and assessment of potential dose dumping.
  • For the 80 mg film-coated presentation, dissolution testing according to its own registered release specification.
  • Stability studies, packaging integrity and labeled storage conditions based on supporting data.

Do not assume a 24-hour release profile or fixed dissolution limits from strength alone.

5. Why Use Verapamil?

Verapamil inhibits L-type calcium channels in cardiac and vascular tissues. It reduces cardiac conduction through the AV node and relaxes arterial smooth muscle.

  • Hypertension: May reduce elevated blood pressure.
  • Angina: Can help prevent certain types of chest pain.
  • Selected supraventricular arrhythmias: May be used for rate control or arrhythmia management when clinically appropriate.

Indications and dosing differ between immediate-release and prolonged-release products. Verapamil is not suitable for every arrhythmia or patient with heart failure.

6. Export and Regulatory Support

Possible B2B documentation includes approved specifications, certificates of analysis and market-specific CTD/ACTD dossiers where available. A prolonged-release designation requires supporting dissolution and regulatory evidence.

WHO-GMP, COPP, Free Sale Certificate, Star Export House status, export destinations, shipping terms and packaging options must be verified from current records.

7. Frequently Asked Questions

Q: Is the 40 mg product definitely prolonged-release?
A: The supplied brief calls it prolonged-release, but this unusual presentation requires confirmation against the approved label and release profile.

Q: Is the 80 mg tablet prolonged-release?
A: The supplied label identifies an 80 mg film-coated tablet only; it does not establish prolonged release.

Q: Can immediate-release and prolonged-release tablets be substituted?
A: Not without prescriber/pharmacist assessment; schedules and release characteristics differ.

Q: Are 120 mg and 240 mg confirmed products?
A: They appear in the general description but not the supplied product labels.

8. Dosage and Administration

Dosing is determined by the prescriber based on the specific product, cardiovascular indication, heart rate, blood pressure, age, liver function and interacting medicines. Do not use a generic once-daily regimen for an unverified 40 mg prolonged-release formulation.

Modified-release tablets generally should not be crushed or chewed; follow the exact approved label for splitting or administration. Do not switch formulations without professional advice.

9. Side Effects and Precautions

  • Common: Constipation, dizziness, headache, flushing, low blood pressure and ankle swelling.
  • Cardiac risks: Bradycardia, AV block, worsening heart failure in susceptible patients and serious hypotension.
  • Interactions: Beta-blockers, digoxin, certain antiarrhythmics, CYP3A4-interacting medicines and grapefruit products may require avoidance or careful monitoring.
  • Contraindications: Certain conduction disorders without a pacemaker, severe hypotension, cardiogenic shock and some heart-failure or accessory-pathway arrhythmia situations.

Seek urgent medical attention for fainting, very slow heartbeat, severe dizziness, shortness of breath or worsening chest pain.

10. Storage Instructions

Store in the original protective packaging according to the temperature and moisture conditions on the approved product label. A universal below-25°C requirement cannot be confirmed from the supplied text. Keep out of reach of children.

For healthcare professional and B2B reference. Product availability, approvals, certifications, manufacturing processes, packaging and prescribing details must be verified for the relevant market.